APOE Gene Test$99

Take this test if you...

Want to know your risk for late-onset Alzheimer's disease
Want to better understand your risk for dementia
Have a family history of Alzheimer's, dementia, cognitive decline or memory issues
Want to be proactive about your brain health and mental wellness
Need to check your APO E genetics at home
Are at risk for heart disease or have high cholesterol levels

How it works

Our 3 step process provides affordable, convenient, and accurate gene testing in the comfort of your home


Order online

Get health tests delivered to your doorstep with just a few clicks.


Collect at home

Complete your APOE test right from your comfy couch, and mail it to our lab with a prepaid shipping label (Monday-Friday).


Get secure results

Receive your test results in 5-6 days & get the clarity you deserve, confidentially.

The APOE test details

Get to know your at-home genetic test

Why test?
Easy collection
Secure results
Test guide
CLIA certified

APOE gene’s full name is Apolipoprotein E genotype. It tells your body how to make the Apolipoprotein E protein (APOE).

When an APOE protein combines with fat, it becomes a lipoprotein. APOE carries cholesterol and other fats through the bloodstream, helping to maintain a healthy cardiovascular system.

APOE appears to play a role in removing beta-amyloid from the brain. Beta-amyloid proteins clump together in plaques that are thought to be involved in the development of Alzheimer's disease. APOE2 seems to be the best and APOE4 seems to be the worst at this clearing process.

Genetic variations can put you at higher risk for late-onset Alzheimer’s disease, dementia, and heart disease. Knowing your risk can help you make the best choices for your health.

Who is empowerDX?

Your trusted source for easy at-home health testing


Is this test an APOE4 test?

The APOE gene has three major variants – APOE2, APOE3, APOE4 – that influence the way your body makes the APOE protein. Evidence from clinical research suggests that APOE4 increases the risk of developing late-onset Alzheimer’s disease, while APOE2 seems to provide protection against dementia. You receive one variant from each parent and your results are displayed as one of these 6 pairs:

  • E2/E2
  • E2/E3
  • E2/E4
  • E3/E3
  • E3/E4
  • E4/E4
How do APOE gene variations occur?

Genes are hereditary. You received one part of the APOE gene from your mom, and the other part from your dad. The pair you received from your parents is your APOE gene variation.

What's in my test kit?

Each kit contains 1 set of instructions, 1 small envelope, 1 plastic tube with a swab inside, 1 biohazard bag, 1 name label sticker, and 1 FedEx Return Pak.

What will my results tell me?

Once you’ve sent your sample back to the lab, we’ll offer your results within 5-6 days. Your results will tell you which variation of the APOE gene you have. Certain variants could increase your risk of getting Alzheimer's or dementia in your lifetime.

How do I use the swab?

The mouth swab is easy! You just swab the inside of both cheeks. It's quick, shallow and painless. Don’t forget to ship your sample the same day you collect it. To ensure stability of the sample, we recommend you collect and ship samples Monday through Thursday only.

Can I order more than one kit?

Absolutely. If you order a kit for someone else, the person who is collecting the sample must create a profile to match the name and date of birth on the collection tube.

PLEASE NOTE: Our genetic tests will be run only ONE TIME per person. If you activate more than one kit under your name, your sample is only processed once.

Important information about my lab results

empowerDX lab results are intended for informational and educational purposes only, with the exception of infectious disease testing which is diagnostic. Information from empowerDX is not meant to serve as treatment advice or treatment recommendation for any health condition. We strongly recommend you review lab results with your physician.

Shipping info

The cost of shipping is included in the price. There's no additional charge for shipping your test to your home or office. Every test kit comes with a prepaid return shipping label that should be used to ship the kit back to our laboratories for analysis and reporting. All tests are shipped to you with FedEx Ground unless otherwise specified.

For more shipping information, please visit our Terms of Service page.

Free health quiz

Not sure what test you need? Take our brief health quiz to find out.

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APOE and mental health articles

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Our customers love us

almost as much as we love them

"...easy to use mouth swab, prepaid return envelope, and fast clear results. I highly recommend the empowerDX APOE Gene Test!"

- Jason

"...easy to use mouth swab, prepaid return envelope, and fast clear results. I highly recommend the empowerDX APOE Gene Test!"

- Jason

Why empowerDX?

At home testing

We send accurate health tests to your door so you can get tested in the comfort of your home.

CLIA-certified laboratories

Get faster, accurate results from real labs and real experts, and get the best care possible right from home.

Secure results

Your health is your business – so our online portal delivers secure test results.

Convenient and easy collection

Get tested on your schedule, and use our step-by-step guide to collect your sample.

Eligible for HSA/FSA

All tests are eligible for HSA and FSA purchasing.

Cutting edge and evidence-based

We use the latest technologies to provide you with the health information you need.

Get APOE gene testing for your organization

The empowerDX APOE Gene Test is available in shipments of 10+ kits

A test guide to better understand the APOE results.

Accurate results for this Alzheimer's risk factor.

Secure online portal access from any device at every location.

Available for volume orders and distribution in all 50 states.

How to collect

With a quick & easy mouth swab from home